Alpha Lipoic Acid * (ALA) is a fatty acid and a potent natural antioxidant that protects cells from damage. It is produced in small amounts in our body, however, these amounts are often not enough for optimal protection and prevention of health problems.

*It is also known as thioctic acid

ALA: Scientific Evidence

Use of ALA during pregnancy enables:

  • Strengthening of fetal membranes1
  • Reduction of inflammation1
  • Slows down tissue remodelling1
ALA: Scientific Evidence

ALA STRENGTHENS the fetal membranes

Tumor necrosis factor (TNF) is one of the factors that cause the fetal membrane to weaken. Increased concentrations of TNF during pregnancy may lead to weakening of the fetal membrane and premature birth.

The study found that alpha-lipoic acid (LA) counteracts the effect of TNF factors and enhances fetal membrane strength (blue bar), reducing the risk of premature birth and miscarriage.

ALA STRENGTHENS the fetal membranes chart

*o▲: p < 0.001

ALA DECREASES pro-inflammatory factors

Prostaglandin E2 (PGE2) is a strong pro-inflammatory factor whose increased concentration in pregnant women can lead to premature birth or miscarriage. The tumor necrosis factor (TNF) leads to an increase in the concentration of PGE2.

The study showed that alpha-lipoic acid (LA) counteracts the effect of TNF factors (blue bar) and thus indirectly reduces the PGE2 levels, reducing the risk of premature birth and miscarriage.

ALA DECREASES pro-inflammatory factors chart

*o▲: p < 0.001

ALA INHIBITS membrane remodelling

Matrix metalloproteinase 9 (MMP 9) is a factor which can, among other things, lead to remodelling and decrease of durability of the fetal membrane, which in turn can lead to premature birth or miscarriage.

The concentration of MMP 9 is significantly increased under the influence of the tumor necrosis factor (TNF). Adding the alpha-lipoic acid (LA) counteracts the effect of TNF (blue bar) and thus reduces the level of MMP 9, significantly reducing the risk of premature birth or miscarriage.

ALA INHIBITS membrane remodelling chart

*o▲: p < 0.001

References

1. Robert M. Moore et all. Alpha-Lipoic Acid Inhibits Tumor Necrosis Factor-Induced Remodeling and Weakening of Human Fetal Membranes. Biology of Reproduction 80, 781–787 (2009);

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